Publications
Patents
J. Fielding, H. Kohlhof, M. Groeppel, R.A. Muehler, D. Vitt, C. Chevrier, M. Zaja, S. Tasler;
Isoxazole-pyrazole derivatives and related compounds as IL-17 and IFN-g inhibitors for treating autoimmune diseases and chronic inflammation;
WO 2019048541
S. Tasler, I. Krimmelbein, J. Kraus, M. Zaja;
Kv1.3 inhibitors and their medical application;
WO 2016146583
S. Tasler, I. Krimmelbein;
Kv1.3 inhibitors and their medical application;
WO 2016146575
J. Leban, S. Tasler, W. Saeb, C. Chevrier;
Preparation of pyrazolylisoxazoles as IL-17 and IFN-gamma production inhibitors for treating autoimmune inflammation;
WO 2012101263
J. Leban, R. Baumgartner, S. Tasler, W. Saeb, C. Chevrier;
Preparation of pyrazolylisoxazoles as IL-17 and IFN-gamma production inhibitors for treating autoimmune inflammation;
WO 2012101261
S. Tasler, D. Vitt, K. Wolf, A. Aschenbrenner, P. Ney;
Preparation of pyrimidinyl aryloxypropanolamines as ß3 adrenergic receptor agonists;
WO 2008090140 A1
J. Ehlert, T. Herz, R. Krauss, M. Kubbutat, M. Lang, W. Saeb, C. Schaechtele, S. Tasler, F. Totzke, U. Zirrgiebel;
2-Arylbenzothiazole analogs as kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of kinase-mediated diseases;
US 2007021446
A. Aschenbrenner, J. Kraus, S. Tasler, A. Wuzik, J.R. Quintana-Ruiz;
Nitro-substituted phenyl-piperazine compounds, their preparation and use in medicaments;
WO 2006069808
A. Aschenbrenner, J. Kraus, S. Tasler, A. Wuzik, J.R. Quintana-Ruiz;
Substituted phenyl-piperazine compounds, their preparation and use in medicaments;
WO 2006069807
T. Herz, R. Krauss, M. Kubbutat, M. Lang, C. Schaechtele, S. Tasler, F. Totzke;
Preparation of benzazole analogues and uses thereof for treating diseases associated with kinases;
US 20060142570
T. Herz, R. Krauss, M. Kubbutat, M. Lang, C. Schaechtele, S. Tasler, F. Totzke;
2,5- And 2,6-disubstituted benzazole analogs useful as protein kinase inhibitors;
WO 2006069740
J. Leban, B. Kramer, R. Baumgartner, K. Aulinger-Fuchs, S. Tasler;
Dihydroorotate dehydrogenase (DHODH) inhibitors and method for their identification;
WO 2004056747
J. Leban, S. Tasler;
Preparation of aromatic compounds as anti-inflammatory, immunomodulatory and antiproliferative agents;
WO 2004056797
Publications out of Professional Career
S. Tasler, R. Baumgartner, D. Behr-Roussel, S. Oger-Roussel, D. Gorny, F. Giuliano, P. Ney; An aryloxypropanolamine hß3-adrenoceptor agonist as bladder smooth muscle relaxant; Eur. J. Pharmaceut. Sci. 2012, 46, 381-387.
S. Tasler, R. Baumgartner, A. Ammendola, J. Schachtner, T. Wieber, M. Blisse, S. Rath, M. Zaja, P. Klahn, U. Quotschalla, P. Ney; Thienopyrimidines as ß3-adrenoceptor agonists: Hit-to-lead optimization; Bioorg. Med. Chem. Lett. 2010, 20, 6108-6115.
S. Tasler, R. Baumgartner, A. Aschenbrenner, A. Ammendola, K. Wolf, T. Wieber, J. Schachtner, M. Blisse, U. Quotschalla, P. Ney; A vHTS approach for the identification of ß-adrenoceptor ligands; Bioorg. Med. Chem. Lett. 2010, 20, 3399-3404.
S. Tasler, O. Müller, T. Wieber, T. Herz, S. Pegoraro, W. Saeb, M. Lang, R. Krauss, F. Totzke, U. Zirrgiebel, J. E. Ehlert, M. H. G. Kubbutat, C. Schächtele; Substituted 2-arylbenzothiazoles as kinase inhibitors: hit-to-lead optimization; Bioorg. Med. Chem. 2009, 17, 6728-6737.
S. Pegoraro, M. Lang, T. Dreker, J. Kraus, S. Hamm, C. Meere, J. Feurle, S. Tasler, S. Prütting, Z. Kuras, V. Visan, S. Grissmer; Inhibitors of potassium channels Kv1.3 and IK-1 as immunosuppressants; Bioorg. Med. Chem. Lett. 2009, 19, 2299-2304.
S. Tasler, O. Müller, T. Wieber, T. Herz, R. Krauss, F. Totzke, M. H. G. Kubbutat, C. Schächtele; N-Substituted 2'-(aminoaryl)benzothiazoles as kinase inhibitors: hit identification and scaffold hopping; Bioorg. Med. Chem. Lett. 2009, 19, 1349-1356.
S. Tasler, J. Kraus, A. Wuzik, O. Müller, A. Aschenbrenner, E. Cubero, R. Pascual, J.-R. Quintana-Ruiz, A. Dordal, R. Mercè, X. Codony; Discovery of 5-HT6 receptor ligands based on virtual HTS; Bioorg. Med. Chem. Lett. 2007, 17, 6224-6229.
S. Tasler, J. Mies, M. Lang; Applicability Aspects of Transition Metal Catalyzed Aromatic Amination Protocols in Medicinal Chemistry; Adv. Synth. Catal. 2007, 349, 2286-2300.
R. Baumgartner, M. Walloschek, M. Kralik, A. Gotschlich, S.Tasler, J. Mies, J. Leban; Dual binding mode of a novel series of DHODH inhibitors; J. Med. Chem. 2006, 49, 1239-1247.
J. Leban, M. Kralik, J. Mies, R. Baumgartner, M. Gassen, S. Tasler; Biphenyl-4-ylcarbamoyl thiophene carboxylic acids as potent DHODH inhibitors; Bioorg. Med. Chem. Lett. 2006, 16, 267-270.
S. Tasler, J. Kraus, S. Pegoraro, A. Aschenbrenner, E. Poggesi, R. Testa, G. Motta, A. Leonardi; Non-competitive inhibitors of metabotropic glutamate receptor 5 (mGluR5); Bioorg. Med. Chem. Lett. 2005, 15, 2876-2880.
Publications out of Academic Career
S. Tasler, B. H. Lipshutz;
Nickel-on-Charcoal Catalyzed Aromatic Aminations and Kumada Couplings: Mechanistic and Synthetic Aspects;
J. Org. Chem. 2003, 68, 1190-1199.
B. H. Lipshutz, S. Tasler, W. Chrisman, B. Spliethoff, B. Tesche;
On the Nature of the 'Heterogeneous' Catalyst: Nickel-on-Charcoal;
J. Org. Chem. 2003, 68, 1177-1189.
B. H. Lipshutz, S. Tasler;
Preparation of Nickel-on-Charcoal (Ni/C): An Improved Protocol;
Adv. Synth. Catal. 2001, 343, 327-329.
G. Bringmann, S. Tasler, R.-M. Pfeifer, M. Breuning;
The directed synthesis of axially chiral ligands, reagents, catalysts, and natural products through the 'lactone methodology';
J. Organomet. Chem. 2002, 661, 49-65.
S. Tasler, G. Bringmann;
Biarylic Biscarbazole Alkaloids: Occurrence, Stereochemistry, Synthesis, and Bioactivity;
Chem. Rec. 2002, 2, 113-126.
S. Tasler, H. Endress, G. Bringmann;
Synthesis of 2,2'-Biscarbazoles by Reductive Biaryl Coupling;
Synthesis 2001, 1993-2002.
G. Bringmann, S. Tasler, H. Endress, J. Mühlbacher;
En route to the First Stereoselective Synthesis of Axially Chiral Biscarbazole Alkaloids;
J. Chem. Soc., Chem. Commun. 2001, 761-762.
G. Bringmann, S. Tasler;
Synthesis of Methylene-Bridged Binary Carbazole Alkaloids and a Related Tricarbazole;
Tetrahedron 2001, 57, 2337-2343.
G. Bringmann, S. Tasler, H. Endress, J. Kraus, K. Messer, M. Wohlfarth, W. Lobin;
Murrastifoline-F: First Total Synthesis, Atropo-Enantiomer Resolution, and Stereoanalysis of an Axially Chiral N,C-Coupled Biaryl Alkaloid;
J. Am. Chem. Soc. 2001, 123, 2703-2711.
K. Peters, E.-M. Peters, S. Tasler, H. Endress, G. Bringmann;
Ethyl 1-methoxy-9-methyl-9H-carbazole-3-carboxylate, C12NH6(OCH3)(CH3)CO2(C2H5);
Z. Kristallogr. NCS 2001, 216, 119-120.
G. Bringmann, S. Tasler;
Oxidative Aryl Coupling Reactions: A Biomimetic Approach to Configurationally Unstable or Axially Chiral Biaryl Natural Products and Related Bioactive Compounds;
Tetrahedron Symposia-in-Print 2001, 57, 331-343.
G. Bringmann, M. Breuning, S. Tasler, H. Endress, C. L. J. Ewers, L. Göbel, K. Peters, E.-M. Peters;
Atropo-Diastereoselective Cleavage of Configurationally Unstable Biaryl Lactones with Alkali Metal Activated Primary 1-Arylethylamines;
Chem. Eur. J. 1999, 5, 3029-3038.
G. Bringmann, M. Breuning, S. Tasler;
The Lactone Concept: An Efficient Pathway to Axially Chiral Natural Products and Useful Reagents;
Synthesis 1999, 525-558.
G. Bringmann, S. Tasler, H. Endress, K. Peters, E.-M. Peters;
Synthesis of Mukonine and Seven Further 1-Oxygenated Carbazole Alkaloids;
Synthesis 1998, 1501-1505.
Book Contributions
G. Bringmann, C. Günther, M. Ochse, O. Schupp, S. Tasler;
Biaryls in Nature: a Multi-Facetted Class of Stereochemically, Biosynthetically, and Pharmacologically Intriguing Secondary Metabolites;
in Prog. Chem. Org. Nat. Prod. (Hrsg.: W. Herz, H. Falk, G. W. Kirby, R. E. Moore, C. Tamm), Springer, Wien, 2001, Vol. 82.
G. Bringmann, S. Tasler;
The Atropisomer-Selective Synthesis of Biologically Active and Synthetically Useful Chiral Biaryls;
in Current Trends in Organic Synthesis (Hrsg.: C. Scolastico, F. Nicotra), Plenum Publishing Corporation, New York, 1999, S. 105-116 (ISBN 0-306-46130-7).
G. Bringmann, M. Breuning, S. Busemann, J. Hinrichs, T. Pabst, R. Stowasser, S. Tasler, A. Wuzik, W. A. Schenk, J. Kümmel, D. Seebach, G. Jaeschke;
Metal-Assisted Synthesis and Application of Axially Chiral Biaryl Systems;
in Selective Reactions of Metal-Activated Molecules (Hrsg.: H. Werner, P. Schreier), Vieweg, Braunschweig, 1998, S. 141-145 (ISBN 3-528-06918-X).
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