EXPERTISE

Skills and Experiences

Research and Preclinical Development

  • Drug Discovery: Hit Identification, Hit-to-Lead, Lead Optimization

  • Small Molecule Synthesis

  • Multidimensional data analysis and conceptual development

  • Selection and analysis of biochemical, cellular and ADME assays, PK and in vivo animal models and toxicology studies

Management

  • Project management, strategic pipeline planning

  • Outsourcing

  • Collaborative Business and Services

  • Team building and Leadership

  • BD activities (e.g. at Bio Europe Partnering Conference)

GMP and GCP

  • CMC

  • RBQM and Quality-by-Design, Risk-Management Plans

  • CSV (Computerized System Validation)

Training

  • Trainings on Leadership, GCP, GMP, CMC, project management, RBQM

Curriculum Vitae

Dr. Stefan Tasler

Professional Career

since 2020: VP Drug Discovery & Development, Vivoryon Therapeutics N.V.

  • Preclinical project pipeline: strategy, budget and forecasts

  • ADME program and pharmacologic evaluation for indication selection

  • Project lead for protease inhibitor program, Hit-to-Lead and Lead Optimization

  • Small molecule drug in Phase II clinical trials: CMC support, GxP compliance


2016-2020: Head of Small Molecules (Site Manager), BioNTech Small Molecules GmbH

  • Establishment of small molecule / ADC project pipeline in immuno-oncology

  • Hit identification / Lead optimization

  • CRO outsourcing

  • Supporting small molecule drug advancement into Phase I

2012-2016: Head of Research, 4SC Discovery GmbH

  • Nourishing sustainable small molecule drug pipeline up to Phase I

  • Project lead for two small molecule preclinical projects (psoriasis, autoimmune diseases), from Hit to IND-enabling studies

  • Coordination of and projects leads for collaborative service business including the i2c technology platform (“idea to candidate”)


2002-2011: Research Scientist then Senior Scientist, MedChem; 4SC AG

  • Small molecule MedChem and pharmacology, lead for internal and collaborative projects (Service business)

  • Target areas: GPCRs, kinases (oncology), ion channels

  • Until 2020: hit identification strategically driven by bioinformatics group with proprietary 4SCan® tool for virtual screening

Education / Academia

2000-2002

Postdoc Position with Prof. B. H. Lipshutz, Department of Chemistry & Biochemistry at the University of California, Santa Barbara, USA; Nickel catalysis in aromatic aminations; DAAD stipend

2000

Doctoral examination in Organic Chemistry and Biochemical Toxicology: Summa cum laude

1996-2000

Doctoral thesis under guidance of Prof. Dr. G. Bringmann, Institut für Organische Chemie, Julius-Maximilians-Universität Würzburg 'Synthesis of atropisomerically pure Biscarbazole Alkaloids'

Contact Us

PCC Tasler - Preclinical Consulting

© Copyrights 2024 | PCC Tasler

All Rights Reserved